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Because the intracellular concentration of charged, largely anionic, impermeant macromolecules is much greater than that in the extracellular fluid. Other antibiotics were also isolated during this period, most notably streptomycin, isolated by Selman Waksman from Streptomyces griseus, which was to prove so effective against tuberculosis. Physiological intoxication is not in and of itself necessarily maladaptive and would not justify a diagnosis of the DSM-IV-TR category substance intoxi- cation.
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